The Toxic Dose of Nicotine: Shattering the Myth. The initial port of call in any discussion like this is to address a long-standing myth. Even today, many high-profile sources list the toxic dose of nicotine (the LD50 – or the dose which will kill about half of individuals exposed) as between 30 and 60 mg.
To put this in context of Vapor Tobacco, this would be about 4 ml of 12 mg/ml e-liquid. Your system does process nicotine quite quickly (your blood nicotine levels will decrease by about 50 % after a couple of hours), so you’d need to consume it all basically in one go, which makes it still a significant tall order.
However, research by Bernd Mayer indicates this value for your toxic dose is utterly indefensible. Within the paper, he details several cases where people consumed much larger amounts of nicotine with only minimal symptoms. On the top of this, the lowest amount of nicotine located in the blood of people that died from nicotine was approximately 20 times greater than existing guidelines. Mayer revises the LD50 of nicotine for an estimated 500 to 1000 mg (or .5 to 1 g) on the basis of those results.
The rest of the question for you is where did the “30 to 60 mg of nicotine will kill you” claim come from? Mayer followed “circular and often misleading references” for a while and ultimately hit on the source: a 1906 textbook from a German toxicologist.
With this basis alone, it’s clear that there are probably some difficulties with trusting this as a source. He was a respected toxicologist at that time, but medical knowledge has advanced massively in the century because it was published, therefore it isn’t surprising that repeating this claim verbatim without further analysis isn’t the most effective idea.
The textbook cited some self-experiments performed in the 19th century, by which experimenters had the equivalent of a few cigarettes’ amount of nicotine and reported seizures and lack of consciousness. It is without saying that there is probably some error in measuring out the dose: otherwise chain-smokers would regularly lose consciousness and possess seizures.
Signs You’ve Had Excessive Nicotine. Vapers aren’t prone to suffer nicotine poisoning, but one thing that’s fairly common has a tad too much nicotine in a single sitting. The biggest tell-tale sign you’ve reached this time is feeling nauseous. You may notice this towards the end of the long vaping session, and it’s effectively the body suggesting to take a break from vaping for quite a while.
Inside my experience, this nausea increases gradually, but it’s better to just have a break whenever you notice it starting. In this way it never becomes too unpleasant, and also you won’t experience the most crucial other initial symptom: vomiting. This isn’t tough to avoid whatsoever, and many vapers may have an escape at the first indication of nausea even without getting advised to do this. You might also get a headache if you’ve overdone it somewhat, but nausea is the easiest thing to take into consideration.
It’s unlikely you’ll actually get to this stage by vaping, but it’s worth knowing the main things to look out for. By far the most serious nicotine poisoning symptoms are much less very likely to occur when you’re vaping, however are worth mentioning anyway. These include coma and seizures (like our nineteenth century experimenters experienced), slowed heartbeat and then in the worst cases, respiratory failure. It may not be as poisonous as many sources claim, however it certainly is still poisonous.
Are You Able To Get Nicotine Poisoning by Vaping? For vapers, the most significant question is whether this is really something to worry about in reality. Would you vape your path to a nicotine overdose? Could you end up with the more serious symptoms of nicotine poisoning?
The easiest method to think about this (and to obtain a straightforward answer!) is to determine just how much e-juice you’d have to vaporize in the space of a couple of hours to hit the minimum toxic dose of about 500 mg.
Utilizing a 12 mg/ml e-juice, you’d must vaporize over 40 ml to approach 500 mg of nicotine vaporised. Realistically, this just isn’t going to take place. For an 18 mg/ml e-liquid, you’d still have to vape almost 28 ml of e-juice in a number of hours to actually have a chance.
This is really only the initial step, though, as well as the nicotine would have to get into the vapour and become absorbed by the body before it might poison you.
Estimating this aspect is a touch tough, but a report from Dr. Farsalinos checked out experienced vapers’ plasma nicotine levels after employing a mod and an 18 mg/ml e-liquid. The analysis didn’t make use of a modern device, but to answer the key question here it’s a lot more than sufficient. The participants vaped 10 puffs in a few minutes, then had an hour or so to djurpj the unit however much they liked.
After five minutes, experienced vapers wound up with about 8 nanograms (billionths of any gram) of nicotine per ml of blood. Following the full 65 minutes, vapers plasma nicotine levels rose to 24.1 ng/ml, although the highest recorded concentration was 48.1 ng/ml.
In Bernd Mayer’s paper, he highlights that this minimum plasma concentration recorded from someone who died from nicotine overdose was 4,000 ng/ml (equal to 4 mg per liter).
Based on the vaper who got the greatest plasma nicotine levels, her or his blood nicotine level will have to be over 80 times higher to arrive at the minimum lethal dose. To pile on yet more implausibility, they’d have to accomplish this in less than two hours. Put simply, they’d need to get about 80 times more nicotine in their blood within twice how long.
This will clearly demonstrate that vapers really can’t overdose on nicotine by utilizing their e-cigarettes as intended. It appears unlikely that it’d even be physically easy to inhale the maximum amount of vapour as you’d need to.